UniprotKB/SwissProt ID: GPM6A_MOUSE (P35802)
Gene Name: Gpm6a
Synonyms: M6a
Organism: Mus musculus (Mouse).
Function: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. Conflictingly, PubMed:22162747 reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a function in actin-independent membrane deformation. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendritic spine (By similarity). Cell projection, filopodium (By similarity). Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons
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