Protein Name: G-protein-signaling modulator 1
|
UniprotKB/SwissProt ID: GPSM1_HUMAN (Q86YR5)
Gene Name: GPSM1
Synonyms: AGS3
Organism: Homo sapiens (Human).
Function: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G- protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
| |
|
Protein disease:
|
| Disease database |
Database Entry |
Disease information | | OMIM | 609491 | G PROTEIN SIGNALING MODULATOR 1; GPSM1 ;;ACTIVATOR OF G PROTEIN SIGNALING 3; AGS3 |
|
Network with metabolic pathway:
|
|
Graphical Visualization of S-nitrosylation Sites:
|
| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
|
