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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Growth factor receptor-bound protein 2

UniprotKB/SwissProt ID: GRB2_HUMAN (P62993)

Gene Name: GRB2

Synonyms: ASH

Organism: Homo sapiens (Human).

Function: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Endosome. Golgi apparatus (By similarity).

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04320Dorso-ventral axis formation
map04664Fc epsilon RI signaling pathway
map05213Endometrial cancer
map05221Acute myeloid leukemia
map05223Non-small cell lung cancer
map04380Osteoclast differentiation
map04540Gap junction
map04650Natural killer cell mediated cytotoxicity
map04660T cell receptor signaling pathway
map04662B cell receptor signaling pathway
map04722Neurotrophin signaling pathway
map04912GnRH signaling pathway
map05160Hepatitis C
map05211Renal cell carcinoma
map05214Glioma
map05215Prostate cancer
map05220Chronic myeloid leukemia
map04010MAPK signaling pathway
map04012ErbB signaling pathway
map04062Chemokine signaling pathway
map04151PI3K-Akt signaling pathway
map04510Focal adhesion
map04630Jak-STAT signaling pathway
map04910Insulin signaling pathway
map05034Alcoholism
map05161Hepatitis B
map05200Pathways in cancer
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000108
IPR000980
IPR001452
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1AZE NMR - A1-56Link
1BM2 X-ray 2.10 A A49-163Link
1BMB X-ray 1.80 A A49-168Link
1CJ1 X-ray 3.00 A A/B/C/D/E/F/G/H/I/J/K/L57-152Link
1FHS NMR - A53-163Link
1FYR X-ray 2.40 A A/B/C/D50-161Link
1GCQ X-ray 1.68 A A/B159-217Link
1GFC NMR - A159-215Link
1GFD NMR - A159-215Link
1GHU NMR - A60-158Link
1GRI X-ray 3.10 A A/B1-217Link
1IO6 NMR - A159-215Link
1JYQ X-ray 2.00 A A/B60-151Link
1JYR X-ray 1.55 A A60-151Link
1JYU X-ray 2.75 A A60-151Link
1QG1 NMR - E58-159Link
1TZE X-ray 2.10 A E55-152Link
1X0N NMR - A58-159Link
1ZFP X-ray 1.80 A E56-153Link
2AOA X-ray 1.99 A A/B55-153Link
2AOB X-ray 1.80 A A/B/C/D55-153Link
2H46 X-ray 1.90 A E53-162Link
2H5K X-ray 3.25 A A/B53-162Link
2HUW X-ray 1.90 A A/B53-162Link
2VVK X-ray 1.60 A A161-214Link
2VWF X-ray 1.58 A A159-214Link
2W0Z X-ray 1.70 A A159-214Link
3C7I X-ray 1.70 A A53-162Link
3IMD X-ray 2.00 A A/B53-163Link
3IMJ X-ray 2.02 A A/B53-163Link
3IN7 X-ray 2.00 A A/C53-163Link
3IN8 X-ray 1.70 A A53-163Link
3KFJ X-ray 2.02 A A53-163Link
3MXC X-ray 2.00 A A55-152Link
3MXY X-ray 2.30 A A55-152Link
3N7Y X-ray 2.02 A A/B/C55-152Link
3N84 X-ray 2.00 A A/B/C/D/E/F53-163Link
3N8M X-ray 2.00 A A53-163Link
3OV1 X-ray 1.60 A A53-163Link
3OVE X-ray 1.82 A A53-163Link
3S8L X-ray 1.71 A A53-163Link
3S8N X-ray 1.71 A A53-163Link
3S8O X-ray 1.85 A A53-163Link
3WA4 X-ray 1.35 A A60-152Link
The S-nitrosylation sites of GRB2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
132GDILKVLNEE C DQNWYKAELN CCEEEEEECC C CCCEEEEEEC 5.49%HC1219483679in vivo