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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Growth factor receptor-bound protein 2

UniprotKB/SwissProt ID: GRB2_MOUSE (Q60631)

Gene Name: Grb2

Organism: Mus musculus (Mouse).

Function: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced. transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus (By similarity). Cytoplasm (By similarity). Endosome (By similarity). Golgi apparatus.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map04320Dorso-ventral axis formation
map04664Fc epsilon RI signaling pathway
map05213Endometrial cancer
map05221Acute myeloid leukemia
map05223Non-small cell lung cancer
map04380Osteoclast differentiation
map04540Gap junction
map04650Natural killer cell mediated cytotoxicity
map04660T cell receptor signaling pathway
map04662B cell receptor signaling pathway
map04722Neurotrophin signaling pathway
map04912GnRH signaling pathway
map05160Hepatitis C
map05211Renal cell carcinoma
map05214Glioma
map05215Prostate cancer
map05220Chronic myeloid leukemia
map04010MAPK signaling pathway
map04012ErbB signaling pathway
map04062Chemokine signaling pathway
map04151PI3K-Akt signaling pathway
map04510Focal adhesion
map04630Jak-STAT signaling pathway
map04910Insulin signaling pathway
map05034Alcoholism
map05161Hepatitis B
map05200Pathways in cancer
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000108
IPR000980
IPR001452
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1GBQ NMR - A1-59Link
1GBR NMR - A1-59Link
2GBQ NMR - A1-59Link
3GBQ NMR - A1-59Link
4GBQ NMR - A1-59Link
The S-nitrosylation sites of GRB2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1198NSDPNWWKGA C HGQTGMFPRN ECCCCEEEEE E CCEEEEEEHH 5.16%MC0321278135in vitro