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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glyoxylate reductase/hydroxypyruvate reductase

UniprotKB/SwissProt ID: GRHPR_MOUSE (Q91Z53)

Gene Name: Grhpr

Synonyms: Glxr

Organism: Mus musculus (Mouse).

Function: Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map00260"Glycine, serine and threonine metabolism"
map00620Pyruvate metabolism
map00630Glyoxylate and dicarboxylate metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR006139
IPR006140

The S-nitrosylation sites of GRHPR_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
129GRAALAQAAD C EVEQWNSDDP HHHHHHHCCC C EEEECCCCCC 5.60%MC0821278135in vitro
257QGVVGAHGLL C RLSDRVDKKL HHHCCCCEEE E CCCCCCCHHH 5.03%MC0321278135in vitro
3123ELAVSLLLTT C RRLPEAIEEV HHHHHHHHHH H HCCHHHHHHH 1.69%MC0621278135in vitro
4123ELAVSLLLTT C RRLPEAIEEV HHHHHHHHHH H HCCHHHHHHH 1.69%MC0622865876in vivo
5288PSHPLLTLKN C VILPHIGSAT CCHHHHHCCC E EECCCCCCCH 1.60%MC0421278135in vitro