dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: Stress-70 protein, mitochondrial

UniprotKB/SwissProt ID: GRP75_HUMAN (P38646)

Gene Name: HSPA9

Synonyms: GRP75, HSPA9B, mt-HSP70

Organism: Homo sapiens (Human).

Function: Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion. Nucleus, nucleolus.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:

Kegg map ID	Pathway	Link
map05152	Tuberculosis
map03018	RNA degradation

Graphical Visualization of S-nitrosylation Sites:

Overview of Protein S-nitrosylation Sites with Functional and Structural Information

InterPro ID	Domain
IPR001023
IPR002048
IPR012725
IPR013126

3D Structure Databases:


3D structure databases
Entry	Method	Resolution (A)	Chain	Positions	View
3N8E	X-ray	2.80 A	A/B	439-597	Link

The S-nitrosylation sites of GRP75_HUMAN

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	Substrate Motifs	PubMed ID	Experiment
1	487	DGQTQVEIKV C QGEREMAGDN	CCCCEEEEEE E CCCCCCCCCC	3.50%	HC09	22178444	-
2	487	DGQTQVEIKV C QGEREMAGDN	CCCCEEEEEE E CCCCCCCCCC	3.50%	HC09	16648260	in vivo
3	487	DGQTQVEIKV C QGEREMAGDN	CCCCEEEEEE E CCCCCCCCCC	3.50%	HC09	20140087	in vivo
4	608	EFKDQLPADE C NKLKEEISKM	HHHHCCCHHH H HHHHHHHHHH	5.83%	HC05	22178444	-
5	608	EFKDQLPADE C NKLKEEISKM	HHHHCCCHHH H HHHHHHHHHH	5.83%	HC05	20140087	in vivo

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