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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutathione reductase, mitochondrial

UniprotKB/SwissProt ID: GSHR_HUMAN (P00390)

Gene Name: GSR

Synonyms: GLUR, GRD1

Organism: Homo sapiens (Human).

Function: Maintains high levels of reduced glutathione in the cytosol.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00480Glutathione metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000815
IPR001100
IPR001327
IPR004099
IPR006322
IPR012999
IPR013027
The S-nitrosylation sites of GSHR_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1107KLGGTCVNVG C VPKKVMWNTA CCCCEEECCC C CCCCCCHHHH 4.05%HC0625040305in vivo
2278RSFDSMISTN C TEELENAGVE CCCCHHHHHH H HHHHHHCCCE 5.26%HC1225040305in vivo
3377VKGIYAVGDV C GKALLTPVAI CCCEEEEEEE C CCCHHHHHHH 5.72%HC0525040305in vivo
4484VVGIHMQGLG C DEMLQGFAVA EEEEEEECCC H HHHHHHHHHH 4.88%HC1225040305in vivo