logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Glutathione S-transferase Mu 3

UniprotKB/SwissProt ID: GSTM3_HUMAN (P21266)

Gene Name: GSTM3

Synonyms: GST5

Organism: Homo sapiens (Human).

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00480Glutathione metabolism
map00980Metabolism of xenobiotics by cytochrome P450
map00982Drug metabolism - cytochrome P450
map05204Chemical carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003081
IPR004045
IPR004046
IPR010987
IPR012335
IPR012336

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3GTU X-ray 2.80 A B/D2-225Link

The S-nitrosylation sites of GSTM3_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
139DTSYEEKRYT C GEAPDYDRSQ CCCEEEEEEC C CCCCCCCHHH 3.25%HC0419483679in vivo
2208IAAYLQSDQF C KMPINNKMAQ HHHHCCCCCC C CCCCCCCCCC 2.83%HC1019483679in vivo