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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutathione S-transferase P

UniprotKB/SwissProt ID: GSTP1_HUMAN (P09211)

Gene Name: GSTP1

Synonyms: FAEES3, GST3

Organism: Homo sapiens (Human).

Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Mitochondrion. Nucleus. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD00614Glutathione S-transferase pi polymorphism, type A
HPRD00614Glutathione S-transferase pi polymorphism, type B
HPRD00614Glutathione S-transferase pi polymorphism, type C
Network with metabolic pathway:
Kegg map ID Pathway Link
map00480Glutathione metabolism
map00980Metabolism of xenobiotics by cytochrome P450
map00982Drug metabolism - cytochrome P450
map05204Chemical carcinogenesis
map05215Prostate cancer
map05200Pathways in cancer
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003082
IPR004045
IPR004046
IPR012335
IPR012336

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
10GS X-ray 2.20 A A/B2-210Link
11GS X-ray 2.30 A A/B1-210Link
12GS X-ray 2.10 A A/B1-210Link
13GS X-ray 1.90 A A/B1-210Link
14GS X-ray 2.80 A A/B2-209Link
16GS X-ray 1.90 A A/B2-209Link
17GS X-ray 1.90 A A/B1-210Link
18GS X-ray 1.90 A A/B2-209Link
19GS X-ray 1.90 A A/B2-210Link
1AQV X-ray 1.94 A A/B2-210Link
1AQW X-ray 1.80 A A/B/C/D2-210Link
1AQX X-ray 2.00 A A/B/C/D2-210Link
1EOG X-ray 2.10 A A/B3-210Link
1EOH X-ray 2.50 A A/B/C/D/E/F/G/H2-210Link
1GSS X-ray 2.80 A A/B2-210Link
1KBN X-ray 2.00 A A/B2-209Link
1LBK X-ray 1.86 A A/B2-202Link
1MD3 X-ray 2.03 A A/B2-209Link
1MD4 X-ray 2.10 A A/B2-209Link
1PGT X-ray 1.80 A A/B1-210Link
1PX6 X-ray 2.10 A A/B2-209Link
1PX7 X-ray 2.03 A A/B2-209Link
1ZGN X-ray 2.10 A A/B2-209Link
20GS X-ray 2.45 A A/B2-209Link
22GS X-ray 1.90 A A/B1-210Link
2A2R X-ray 1.40 A A/B2-209Link
2A2S X-ray 1.70 A A/B2-209Link
2GSS X-ray 1.90 A A/B2-210Link
2J9H X-ray 2.40 A A/B2-210Link
2PGT X-ray 1.90 A A/B1-210Link
3CSH X-ray 1.55 A A/B2-210Link
3CSI X-ray 1.90 A A/B/C/D2-210Link
3CSJ X-ray 1.90 A A/B2-210Link
3DD3 X-ray 2.25 A A/B1-210Link
3DGQ X-ray 1.60 A A/B1-210Link
3GSS X-ray 1.90 A A/B2-210Link
3GUS X-ray 1.53 A A/B2-210Link
3HJM X-ray 2.10 A A/B/C/D2-210Link
3HJO X-ray 1.95 A A/B2-210Link
3HKR X-ray 1.80 A A/B2-210Link
3IE3 X-ray 1.80 A A/B2-210Link
3KM6 X-ray 2.10 A A/B2-210Link
3KMN X-ray 1.80 A A/B2-210Link
3KMO X-ray 2.60 A A/B2-210Link
3N9J X-ray 1.85 A A/B1-210Link
3PGT X-ray 2.14 A A/B1-210Link
4GSS X-ray 2.50 A A/B2-209Link
4PGT X-ray 2.10 A A/B1-210Link
5GSS X-ray 1.95 A A/B2-210Link
6GSS X-ray 1.90 A A/B2-210Link
7GSS X-ray 2.20 A A/B2-210Link
8GSS X-ray 1.90 A A/B/C2-210Link
9GSS X-ray 1.97 A A/B2-210Link

The S-nitrosylation sites of GSTP1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
148TWQEGSLKAS C LYGQLPKFQD HCCCCCCCCC C CCCCCCEEEE 3.97%HC0425040305in vivo
248TWQEGSLKAS C LYGQLPKFQD HCCCCCCCCC C CCCCCCEEEE 3.97%HC0419483679in vivo