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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutathione S-transferase theta-2

UniprotKB/SwissProt ID: GSTT2_RAT (P30713)

Gene Name: Gstt2

Organism: Rattus norvegicus (Rat).

Function: Catalyzes the inactivation of reactive sulfate esters in carcinogenic arylmethanols. Highest activity towards ethacrynic acid and cumene hydroperoxide.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00480Glutathione metabolism
map00980Metabolism of xenobiotics by cytochrome P450
map00982Drug metabolism - cytochrome P450
map05204Chemical carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004045
IPR004046
IPR010987
IPR012335
IPR012336

The S-nitrosylation sites of GSTT2_RAT

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
150HLSEQFSQVN C LKKVPVLKDG CCCHHHHHHC C CCCCCEEEEC 6.56%RC0222178444-
250HLSEQFSQVN C LKKVPVLKDG CCCHHHHHHC C CCCCCEEEEC 6.56%RC0216418269in vitro
350HLSEQFSQVN C LKKVPVLKDG CCCHHHHHHC C CCCCCEEEEC 6.56%RC0219101475-