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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: General transcription factor II-I

UniprotKB/SwissProt ID: GTF2I_HUMAN (P78347)

Gene Name: GTF2I

Synonyms: BAP135, WBSCR6

Organism: Homo sapiens (Human).

Function: Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus. Note=Colocalizes with BTK in the cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03022Basal transcription factors
map05168Herpes simplex infection
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR004212

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2D9B NMR - A102-197Link
2DN4 NMR - A361-446Link
2ED2 NMR - A466-551Link
2EJE NMR - A854-954Link

The S-nitrosylation sites of GTF2I_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1475KLRKMVDQLF C KKFAEALGST HHHHHHHHHH H HHHHHHHCCC 6.78%HC0122178444-
2475KLRKMVDQLF C KKFAEALGST HHHHHHHHHH H HHHHHHHCCC 6.78%HC0120140087in vivo