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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: GMP synthase [glutamine-hydrolyzing]

UniprotKB/SwissProt ID: GUAA_HUMAN (P49915)

Gene Name: GMPS

Organism: Homo sapiens (Human).

Function: Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00230Purine metabolism
map00983Drug metabolism - other enzymes
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000991
IPR001674
IPR004479
IPR004739
IPR006220
IPR011702
IPR012998
IPR014729

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2VPI X-ray 2.40 A A/B25-219Link
2VXO X-ray 2.50 A A/B20-693Link

The S-nitrosylation sites of GUAA_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1449PGPGLAIRVI C AEEPYICKDF CCCCCEEEEE C CCCHHHHHHH 3.40%HC0419483679in vivo
2456RVICAEEPYI C KDFPETNNIL EEECCCCHHH H HHHHHHHHHH 2.60%HC1219483679in vivo