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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Histone H3.1

UniprotKB/SwissProt ID: H31_HUMAN (P68431)

Gene Name: HIST1H3A

Synonyms: H3FA

Organism: Homo sapiens (Human).

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Chromosome.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map05322Systemic lupus erythematosus
map05034Alcoholism
map05202Transcriptional misregulation in cancer
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000164
IPR007125
IPR009072

The S-nitrosylation sites of H31_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
197SSAVMALQEA C EAYLVGLFED HHHHHHHHHH H HHHHHHHHHH 2.79%HC1225040305in vivo