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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Histone H3.2

UniprotKB/SwissProt ID: H32_MOUSE (P84228)

Gene Name: Hist1h3b

Synonyms: H3-53, H3.2, H3b

Organism: Mus musculus (Mouse).

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Chromosome.

Network with metabolic pathway:
Kegg map ID Pathway Link
map05322Systemic lupus erythematosus
map05034Alcoholism
map05202Transcriptional misregulation in cancer
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000164
IPR007125
IPR009072

The S-nitrosylation sites of H32_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1111LVGLFEDTNL C AIHAKRVTIM HHHHHHHHHH H HHHCCCEEEE 3.47%MC0222865876in vivo