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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Histone acetyltransferase type B catalytic subunit

UniprotKB/SwissProt ID: HAT1_MOUSE (Q8BY71)

Gene Name: Hat1

Organism: Mus musculus (Mouse).

Function: Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus matrix (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map05034Alcoholism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information

The S-nitrosylation sites of HAT1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
124AVEKKLAEYK C NTNTAIELKL HHHCCCCCCC C CCCCEEEEEE 8.11%MC0120925432in vivo