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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

UniprotKB/SwissProt ID: HCDH_MOUSE (Q61425)

Gene Name: Hadh

Synonyms: Hadhsc, Mschad, Schad

Organism: Mus musculus (Mouse).

Function: Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00062Fatty acid elongation
map00071Fatty acid metabolism
map00280"Valine, leucine and isoleucine degradation"
map00310Lysine degradation
map00380Tryptophan metabolism
map00650Butanoate metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR006108
IPR006176
IPR006180
IPR008927
IPR013328

The S-nitrosylation sites of HCDH_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
199GDEFVEKTLS C LSTSTDAASV CCHHHHHHHH H CCCCCCHHHH 3.80%MC1021278135in vitro
299GDEFVEKTLS C LSTSTDAASV CCHHHHHHHH H CCCCCCHHHH 3.80%MC1022865876in vivo
3201QKTFESLVDF C KTLGKHPVSC HHHHHHHHHH H HHCCCEEEEE 2.59%MC0221278135in vitro
4201QKTFESLVDF C KTLGKHPVSC HHHHHHHHHH H HHCCCEEEEE 2.59%MC0222865876in vivo
5211CKTLGKHPVS C KDTPGFIVNR HHHCCCEEEE E CCCCCHHHHH 4.75%MC0821278135in vitro
6211CKTLGKHPVS C KDTPGFIVNR HHHCCCEEEE E CCCCCHHHHH 4.75%MC0822865876in vivo