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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Histone deacetylase 2

UniprotKB/SwissProt ID: HDAC2_MOUSE (P70288)

Gene Name: Hdac2

Synonyms: Yy1bp

Organism: Mus musculus (Mouse).

Function: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA- replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04330Notch signaling pathway
map05220Chronic myeloid leukemia
map04110Cell cycle
map05016Huntington's disease
map05034Alcoholism
map05169Epstein-Barr virus infection
map05200Pathways in cancer
map05202Transcriptional misregulation in cancer
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000286
IPR003084

The S-nitrosylation sites of HDAC2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1262MYQPSAVVLQ C GADSLSGDRL HHCCCEEEEE C CCHHHCCCCC 4.19%MC0322178444-
2262MYQPSAVVLQ C GADSLSGDRL HHCCCEEEEE C CCHHHCCCCC 4.19%MC0318754010-
3274ADSLSGDRLG C FNLTVKGHAK CHHHCCCCCC C EEECHHHHHH 2.12%MC0222178444-
4274ADSLSGDRLG C FNLTVKGHAK CHHHCCCCCC C EEECHHHHHH 2.12%MC0218754010-