logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Hydroxymethylglutaryl-CoA synthase, mitochondrial

UniprotKB/SwissProt ID: HMCS2_MOUSE (P54869)

Gene Name: Hmgcs2

Organism: Mus musculus (Mouse).

Function: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00072Synthesis and degradation of ketone bodies
map00280"Valine, leucine and isoleucine degradation"
map00650Butanoate metabolism
map00900Terpenoid backbone biosynthesis
map03320PPAR signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000590
IPR010122
IPR013528
IPR013746

The S-nitrosylation sites of HMCS2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
196VGLGQTRMGF C SVQEDINSLC CCCCEEEECC C CCCCCHHHHH 3.01%MC1020837516in vivo
2106CSVQEDINSL C LTVVQRLMER CCCCCCHHHH H HHHHHHHHHH 2.76%MC0220837516in vivo
3269IQCYLRALDR C YAAYRKKIQN EHHHHHHHHH H HHHHHHHHHH 2.43%MC0220837516in vivo
4305VQYMIFHTPF C KMVQKSLARL CCEEEECCCC C HHHHHHHHHH 2.68%MC0320837516in vivo