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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hydroxymethylglutaryl-CoA lyase, mitochondrial

UniprotKB/SwissProt ID: HMGCL_MOUSE (P38060)

Gene Name: Hmgcl

Organism: Mus musculus (Mouse).

Function: Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism. Ketone bodies (beta- hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix. Peroxisome. Note=Unprocessed form is peroxisomal.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00072Synthesis and degradation of ketone bodies
map00280"Valine, leucine and isoleucine degradation"
map00650Butanoate metabolism
map04146Peroxisome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000138
IPR000891
IPR013785

The S-nitrosylation sites of HMGCL_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1141SELFTRKNAN C SIEESFQRFA CHHHHHHHHC C CHHHHHHHHH 3.94%MC1022178444-
2141SELFTRKNAN C SIEESFQRFA CHHHHHHHHC C CHHHHHHHHH 3.94%MC1021278135in vitro
3141SELFTRKNAN C SIEESFQRFA CHHHHHHHHC C CHHHHHHHHH 3.94%MC1020837516in vivo
4307QKLLEAGDFI C QALNRKTSSK HHHHHHHHHH H HHHCCCCCHH 1.63%MC0222178444-
5307QKLLEAGDFI C QALNRKTSSK HHHHHHHHHH H HHHCCCCCHH 1.63%MC0221278135in vitro
6307QKLLEAGDFI C QALNRKTSSK HHHHHHHHHH H HHHCCCCCHH 1.63%MC0220837516in vivo
7323KTSSKVAQAT C KL-------- CCCHHHHHHC C CC 4.78%MC1322865876in vivo