logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Heterogeneous nuclear ribonucleoprotein L

UniprotKB/SwissProt ID: HNRPL_HUMAN (P14866)

Gene Name: HNRNPL

Synonyms: HNRPL

Organism: Homo sapiens (Human).

Function: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000504
IPR000977
IPR006536
IPR012677

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3R27 X-ray 2.04 A A/B90-180Link
3TO8 X-ray 1.82 A A380-589Link

The S-nitrosylation sites of HNRPL_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1260SLNGADIYSG C CTLKIEYAKP CCCCCCCCCC C CCCCCCCCCC 1.00%HC0819483679in vivo
2261LNGADIYSGC C TLKIEYAKPT CCCCCCCCCC C CCCCCCCCCC 5.95%HC0619483679in vivo
3452NFMFGQKLNV C VSKQPAIMPG CCCCCCCCCC C CCCCCCCCCC 2.52%HC0619483679in vivo
4581NGPYPYTLKL C FSTAQHAS--   2.12%HC0322178444-
5581NGPYPYTLKL C FSTAQHAS--   2.12%HC0320140087in vivo