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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Heterogeneous nuclear ribonucleoprotein M

UniprotKB/SwissProt ID: HNRPM_HUMAN (P52272)

Gene Name: HNRNPM

Synonyms: HNRPM, NAGR1

Organism: Homo sapiens (Human).

Function: Pre-mRNA binding protein in vivo, binds avidly to poly(G) and poly(U) RNA homopolymers in vitro. Involved in splicing. Acts as a receptor for carcinoembryonic antigen in Kupffer cells, may initiate a series of signaling events leading to tyrosine phosphorylation of proteins and induction of IL-1 alpha, IL-6, IL-10 and tumor necrosis factor alpha cytokines.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus, nucleolus.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03040Spliceosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000504
IPR012677

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2DGV NMR - A652-729Link
2DH9 NMR - A655-729Link
2DO0 NMR - A196-295Link
2OT8 X-ray 3.10 A C/D41-70Link

The S-nitrosylation sites of HNRPM_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1114LMDAEGKSRG C AVVEFKMEES EECCCCCCCC E EEEEECCHHH 2.23%HC0919483679in vivo
2676WKMLKDKFNE C GHVLYADIKM HHHHHHHHHH C CCEEEEEEEE 4.85%HC0522178444-
3676WKMLKDKFNE C GHVLYADIKM HHHHHHHHHH C CCEEEEEEEE 4.85%HC0520140087in vivo
4694IKMENGKSKG C GVVKFESPEV EEECCCCCCC E EEEEECCHHH 4.26%HC0919483679in vivo