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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Heterogeneous nuclear ribonucleoprotein U

UniprotKB/SwissProt ID: HNRPU_HUMAN (Q00839)

Gene Name: HNRNPU

Synonyms: HNRPU, SAFA, U21.1

Organism: Homo sapiens (Human).

Function: Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single- stranded DNA and RNA.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus. Cytoplasm. Cell surface. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Also found associated with the cell surface.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map03040Spliceosome
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001870
IPR003034
IPR003877

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1ZRJ NMR - A23-42Link

The S-nitrosylation sites of HNRPU_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1562LNTLLQRAPQ C LGKFIEIAAR HHHHHHHHHH H HHHHHHHCCC 5.42%HC0619483679in vivo