UniprotKB/SwissProt ID: HOP_MOUSE (Q8R1H0)
Gene Name: Hopx
Synonyms: Hod, Hop, Ob1
Organism: Mus musculus (Mouse).
Function: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Note=According to PubMed:14516659 it is cytoplasmic.
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PDB :
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