Protein Name: Hydroxyacid-oxoacid transhydrogenase, mitochondrial
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UniprotKB/SwissProt ID: HOT_MOUSE (Q8R0N6)
Gene Name: Adhfe1
Organism: Mus musculus (Mouse).
Function: Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2- hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion.
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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