Protein Name: Hypoxanthine-guanine phosphoribosyltransferase
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UniprotKB/SwissProt ID: HPRT_HUMAN (P00492)
Gene Name: HPRT1
Synonyms: HPRT
Organism: Homo sapiens (Human).
Function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.
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PDB :
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Protein disease:
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| Disease database |
Database Entry |
Disease information | | HPRD | 02388 | Gout, HPRT-related | | HPRD | 02388 | HPRT deficiency, partial | | HPRD | 02388 | Lesch-Nyhan syndrome | | HPRD | 02388 | Lesch-Nyhan syndrome, neurologic variant |
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Network with metabolic pathway:
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Graphical Visualization of S-nitrosylation Sites:
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| Overview of Protein S-nitrosylation Sites with Functional and Structural Information |  |
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