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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hypoxanthine-guanine phosphoribosyltransferase

UniprotKB/SwissProt ID: HPRT_MOUSE (P00493)

Gene Name: Hprt1

Synonyms: Hprt

Organism: Mus musculus (Mouse).

Function: Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00230Purine metabolism
map00983Drug metabolism - other enzymes
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000836
IPR002375
IPR005904

The S-nitrosylation sites of HPRT_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1106TVDFIRLKSY C NDQSTGDIKV EEEEEEEEEC C CCCCCCCCEE 6.13%MC0322178444-
2106TVDFIRLKSY C NDQSTGDIKV EEEEEEEEEC C CCCCCCCCEE 6.13%MC0319101475-
3106TVDFIRLKSY C NDQSTGDIKV EEEEEEEEEC C CCCCCCCCEE 6.13%MC0322865876in vivo