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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Heat shock protein HSP 90-alpha

UniprotKB/SwissProt ID: HS90A_HUMAN (P07900)

Gene Name: HSP90AA1

Synonyms: HSP90A, HSPC1, HSPCA

Organism: Homo sapiens (Human).

Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

PDB :
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Network with metabolic pathway:
Kegg map ID Pathway Link
map04612Antigen processing and presentation
map04621NOD-like receptor signaling pathway
map05215Prostate cancer
map04151PI3K-Akt signaling pathway
map04914Progesterone-mediated oocyte maturation
map05200Pathways in cancer
map04141Protein processing in endoplasmic reticulum
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001404
IPR003594
3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1BYQ X-ray 1.50 A A9-236Link
1OSF X-ray 1.75 A A9-223Link
1UY6 X-ray 1.90 A A1-236Link
1UY7 X-ray 1.90 A A1-236Link
1UY8 X-ray 1.98 A A1-236Link
1UY9 X-ray 2.00 A A1-236Link
1UYC X-ray 2.00 A A1-236Link
1UYD X-ray 2.00 A A1-236Link
1UYE X-ray 2.00 A A1-236Link
1UYF X-ray 2.00 A A1-236Link
1UYG X-ray 2.00 A A1-236Link
1UYH X-ray 2.20 A A1-236Link
1UYI X-ray 2.00 A A1-236Link
1UYK X-ray 2.00 A A1-236Link
1UYL X-ray 1.40 A A1-236Link
1YC1 X-ray 1.70 A A9-235Link
1YC3 X-ray 2.12 A A9-235Link
1YC4 X-ray 1.81 A A9-235Link
1YER X-ray 1.65 A A9-236Link
1YES X-ray 2.20 A A9-236Link
1YET X-ray 1.90 A A9-236Link
2BSM X-ray 2.05 A A2-235Link
2BT0 X-ray 1.90 A A/B2-235Link
2BUG NMR - B-Link
2BYH X-ray 1.90 A A11-235Link
2BYI X-ray 1.60 A A11-235Link
2BZ5 X-ray 1.90 A A/B2-235Link
2C2L X-ray 3.30 A E/F/G/H724-732Link
2CCS X-ray 1.79 A A1-236Link
2CCT X-ray 2.30 A A1-236Link
2CCU X-ray 2.70 A A1-236Link
2CDD X-ray 1.90 A A/B1-236Link
2FWY X-ray 2.10 A A1-236Link
2FWZ X-ray 2.10 A A1-236Link
2H55 X-ray 2.00 A A1-236Link
2JJC X-ray 1.95 A A9-223Link
2K5B NMR - A14-223Link
2QF6 X-ray 3.10 A A/B/C/D17-223Link
2QFO X-ray 1.68 A A/B17-223Link
2QG0 X-ray 1.85 A A/B17-223Link
2QG2 X-ray 1.80 A A17-223Link
2UWD X-ray 1.90 A A2-235Link
2VCI X-ray 2.00 A A1-236Link
2VCJ X-ray 2.50 A A1-236Link
2WI1 X-ray 2.30 A A1-236Link
2WI2 X-ray 2.09 A A/B1-236Link
2WI3 X-ray 1.90 A A1-236Link
2WI4 X-ray 2.40 A A1-236Link
2WI5 X-ray 2.10 A A1-236Link
2WI6 X-ray 2.18 A A1-236Link
2WI7 X-ray 2.50 A A1-236Link
2XAB X-ray 1.90 A A/B9-236Link
2XDK X-ray 1.97 A A9-236Link
2XDL X-ray 1.98 A A9-236Link
2XDS X-ray 1.97 A A9-236Link
2XDU X-ray 1.74 A A14-224Link
2XDX X-ray 2.42 A A9-236Link
2XHR X-ray 2.20 A A9-236Link
2XHT X-ray 2.27 A A9-236Link
2XHX X-ray 2.80 A A9-236Link
2XJG X-ray 2.25 A A9-236Link
2XJJ X-ray 1.90 A A/B9-236Link
2XJX X-ray 1.66 A A9-236Link
2XK2 X-ray 1.95 A A9-236Link
2YE2 X-ray 1.90 A A9-236Link
2YE3 X-ray 1.95 A A9-236Link
2YE4 X-ray 2.30 A A9-236Link
2YE5 X-ray 1.73 A A9-236Link
2YE6 X-ray 2.56 A A9-236Link
2YE7 X-ray 2.20 A A9-236Link
2YE8 X-ray 2.30 A A9-236Link
2YE9 X-ray 2.20 A A9-236Link
2YEA X-ray 1.73 A A9-236Link
2YEB X-ray 2.40 A A9-236Link
2YEC X-ray 2.10 A A9-236Link
2YED X-ray 2.10 A A9-236Link
2YEE X-ray 2.30 A A9-236Link
2YEF X-ray 1.55 A A9-236Link
2YEG X-ray 2.50 A A/B9-236Link
2YEH X-ray 2.10 A A9-236Link
2YEI X-ray 2.20 A A9-236Link
2YEJ X-ray 2.20 A A9-236Link
2YI0 X-ray 1.60 A A1-229Link
2YI5 X-ray 2.50 A A1-229Link
2YI6 X-ray 1.80 A A1-229Link
2YI7 X-ray 1.40 A A1-229Link
2YJW X-ray 1.61 A A18-223Link
2YJX X-ray 1.83 A A18-223Link
2YK2 X-ray 1.74 A A18-223Link
2YK9 X-ray 1.32 A A18-223Link
2YKB X-ray 1.93 A A18-223Link
2YKC X-ray 1.67 A A18-223Link
2YKE X-ray 1.43 A A18-223Link
2YKI X-ray 1.67 A A18-223Link
2YKJ X-ray 1.46 A A18-223Link
3B24 X-ray 1.70 A A/B9-236Link
3B25 X-ray 1.75 A A9-236Link
3B26 X-ray 2.10 A A/B9-236Link
3B27 X-ray 1.50 A A9-236Link
3B28 X-ray 1.35 A A/B9-236Link
3BM9 X-ray 1.60 A A14-236Link
3BMY X-ray 1.60 A A14-236Link
3D0B X-ray 1.74 A A1-232Link
3EKO X-ray 1.55 A A/B9-225Link
3EKR X-ray 2.00 A A/B9-225Link
3FT5 X-ray 1.90 A A9-236Link
3FT8 X-ray 2.00 A A9-236Link
3HEK X-ray 1.95 A A/B9-225Link
3HHU X-ray 1.59 A A/B1-224Link
3HYY X-ray 1.90 A A9-236Link
3HYZ X-ray 2.30 A A/B9-236Link
3HZ1 X-ray 2.30 A A9-236Link
3HZ5 X-ray 1.90 A A9-236Link
3INW X-ray 1.95 A A10-236Link
3INX X-ray 1.75 A A10-236Link
3K97 X-ray 1.95 A A9-236Link
3K98 X-ray 2.40 A A/B9-225Link
3K99 X-ray 2.10 A A/B/C/D9-225Link
3MNR X-ray 1.90 A P1-232Link
3O0I X-ray 1.47 A A1-236Link
3OW6 X-ray 1.80 A A17-223Link
3OWB X-ray 2.05 A A17-223Link
3OWD X-ray 1.63 A A17-223Link
3Q6M X-ray 3.00 A A/B/C293-732Link
3Q6N X-ray 3.05 A A/B/C/D/E/F293-732Link
3QDD X-ray 1.79 A A1-236Link
3QTF X-ray 1.57 A A14-236Link
3R4M X-ray 1.70 A A9-236Link
3R4N X-ray 2.00 A A/B9-225Link
3R4O X-ray 2.65 A A/B9-225Link
3R4P X-ray 1.70 A A/B9-225Link
3R91 X-ray 1.58 A A14-236Link
3R92 X-ray 1.58 A A14-236Link
3RKZ X-ray 1.57 A A14-236Link
3RLP X-ray 1.70 A A/B9-225Link
3RLQ X-ray 1.90 A A/B9-225Link
3RLR X-ray 1.70 A A/B9-225Link
3T0H X-ray 1.20 A A9-236Link
3T0Z X-ray 2.19 A A9-236Link
3T10 X-ray 1.24 A A9-236Link
3T1K X-ray 1.50 A A/B9-236Link
3T2S X-ray 1.50 A A/B9-236Link
3TUH X-ray 1.80 A A/B16-224Link
3VHA X-ray 1.39 A A9-236Link
3VHC X-ray 1.41 A A9-236Link
3VHD X-ray 1.52 A A/B9-236Link
3WHA X-ray 1.30 A A/B9-236Link
4AIF X-ray 2.01 A D/E726-732Link
4AWO X-ray 1.70 A A/B9-236Link
4AWP X-ray 1.82 A A/B9-236Link
4AWQ X-ray 1.60 A A/B9-236Link
4B7P X-ray 1.70 A A9-236Link
4BQJ X-ray 2.00 A A9-236Link
4EEH X-ray 1.60 A A9-236Link
4EFT X-ray 2.12 A A9-236Link
4EFU X-ray 2.00 A A9-236Link
4EGH X-ray 1.60 A A9-236Link
4EGI X-ray 1.79 A A9-236Link
4EGK X-ray 1.69 A A9-236Link
4FCP X-ray 2.00 A A/B1-236Link
4FCQ X-ray 2.15 A A1-236Link
4FCR X-ray 1.70 A A1-236Link
4HY6 X-ray 1.65 A A9-236Link
4JQL X-ray 1.72 A A9-236Link
4NH7 X-ray 2.00 A A/B9-236Link
4NH8 X-ray 1.65 A A9-236Link
The S-nitrosylation sites of HS90A_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1420KVIRKNLVKK C LELFTELAED HHHHHHHHHH H HHHHHHHHCC 2.71%HC0922178444-
2420KVIRKNLVKK C LELFTELAED HHHHHHHHHH H HHHHHHHHCC 2.71%HC0920140087in vivo
3481GDEMVSLKDY C TRMKENQKHI CCCCEEHHHH H HHCCCCCCEE 2.52%HC0422178444-
4481GDEMVSLKDY C TRMKENQKHI CCCCEEHHHH H HHCCCCCCEE 2.52%HC0417629318in vitro
5597VVSNRLVTSP C CIVTSTYGWT EEEEEECCCC E EEEECCCCCC 2.18%HC1222178444-
6597VVSNRLVTSP C CIVTSTYGWT EEEEEECCCC E EEEECCCCCC 2.18%HC1215937123-
7598VSNRLVTSPC C IVTSTYGWTA EEEEECCCCE E EEECCCCCCH 2.96%HC1122178444-
8598VSNRLVTSPC C IVTSTYGWTA EEEEECCCCE E EEECCCCCCH 2.96%HC1115937123-