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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Heat shock protein HSP 90-alpha

UniprotKB/SwissProt ID: HS90A_MOUSE (P07901)

Gene Name: Hsp90aa1

Synonyms: Hsp86, Hsp86-1, Hspca

Organism: Mus musculus (Mouse).

Function: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map04612Antigen processing and presentation
map04621NOD-like receptor signaling pathway
map05215Prostate cancer
map04151PI3K-Akt signaling pathway
map04914Progesterone-mediated oocyte maturation
map05200Pathways in cancer
map04141Protein processing in endoplasmic reticulum
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001404
IPR003594

The S-nitrosylation sites of HS90A_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1530IYMIEPIDEY C VQQLKEFEGK EEECCCHHHH H HHHHHHCCCC 1.78%MC0422865876in vivo
2573EEKKTKFENL C KIMKDILEKK HHHHHHHHHH H HHHHHHCCCC 4.18%MC0124926564-
3598VVSNRLVTSP C CIVTSTYGWT EEEEEECCCC E EEEECCCCCC 2.18%MC1322865876in vivo
4599VSNRLVTSPC C IVTSTYGWTA EEEEECCCCE E EEECCCCCCH 2.96%MC0122865876in vivo