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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Hexokinase-2

UniprotKB/SwissProt ID: HXK2_MOUSE (O08528)

Gene Name: Hk2

Organism: Mus musculus (Mouse).

Function:

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map00010Glycolysis / Gluconeogenesis
map00051Fructose and mannose metabolism
map00052Galactose metabolism
map00500Starch and sucrose metabolism
map00520Amino sugar and nucleotide sugar metabolism
map00524Butirosin and neomycin biosynthesis
map04930Type II diabetes mellitus
map04973Carbohydrate digestion and absorption
map04066HIF-1 signaling pathway
map04910Insulin signaling pathway
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001312
The S-nitrosylation sites of HXK2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1158LPLGFTFSFP C HQTKLDESFL CCEEEEEEEC C CCCCCCCEEE 3.32%MC0722865876in vivo
2256DMVEGDEGRM C INMEWGAFGD CCCCCCCCCE E EEEEECCCCC 1.64%MC0922865876in vivo
3368RLGLSPLQED C VATHRICQIV HCCCCCCHHH H HHHHHHHHHH 1.90%MC0421278135in vitro
4375QEDCVATHRI C QIVSTRSASL HHHHHHHHHH H HHHHHHHHHH 1.97%MC0221278135in vitro
5386QIVSTRSASL C AATLAAVLWR HHHHHHHHHH H HHHHHHHHHH 1.93%MC1321278135in vitro
6386QIVSTRSASL C AATLAAVLWR HHHHHHHHHH H HHHHHHHHHH 1.93%MC1322865876in vivo
7438HKAVRRLVPD C DVRFLRSEDG HHHHHHHCCC C CEEEEECCCC 4.22%MC0221278135in vitro
8517APVKMLPTYV C ATPDGTEKGD CCEEEEEEEE C CCCCCCCCEE 2.16%MC1121278135in vitro
9606LPLGFTFSFP C QQNSLDQSIL EEEEEEEEEC C CCCCCCCCEE 6.48%MC1321278135in vitro
10628KWTKGFKASG C EGEDVVTLLK EEECCCCCCC C CHHHHHHHHH 5.86%MC0121278135in vitro
11704ELVDGEEGRM C VNMEWGAFGD CCCCCCCCCE E EEEEECCCCC 1.60%MC0922865876in vivo
12717MEWGAFGDNG C LDDLRTVFDV EEECCCCCCC C CCCCCCHHHH 4.76%MC0422865876in vivo
13794TKFLSQIESD C LALLQVRAIL CCHHHHEECC C CHHHHHHHHH 3.14%MC0521278135in vitro
14813ILRHLGLEST C DDSIIVKEVC HHHHCCCCCC H HHHHHHHHHH 8.34%MC0121278135in vitro
15813ILRHLGLEST C DDSIIVKEVC HHHHCCCCCC H HHHHHHHHHH 8.34%MC0122865876in vivo
16834TVVARRAAQL C GAGMAAVVDK HHHHHHHHHH H HHHHHHHHHH 2.03%MC1321278135in vitro
17886HETVRDLAPK C DVSFLESEDG HHHHHHHCCC C CEEEEECCCC 6.42%MC1322865876in vivo
18909KGAALITAVA C RIREAGQR-- HHHHHHHHHH H HHHHCCCC 2.74%MC1221278135in vitro
19909KGAALITAVA C RIREAGQR-- HHHHHHHHHH H HHHHCCCC 2.74%MC1222865876in vivo