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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Calpastatin

UniprotKB/SwissProt ID: ICAL_HUMAN (P20810)

Gene Name: CAST

Organism: Homo sapiens (Human).

Function: Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001259

The S-nitrosylation sites of ICAL_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1408AAPAPVSEAV C RTSMCSIQSA CCCCCCCCCC C CCCCCCCCCC 5.18%HC1222178444-
2408AAPAPVSEAV C RTSMCSIQSA CCCCCCCCCC C CCCCCCCCCC 5.18%HC1220140087in vivo
3413VSEAVCRTSM C SIQSAPPEPA CCCCCCCCCC C CCCCCCCCCC 3.04%HC122212679
(Cys400)
in vitro
4661IDALSGDLDS C PSTTETSQNT CCCCCCCCCC C CCCCCCCCCC 2.85%HC1222178444-
5661IDALSGDLDS C PSTTETSQNT CCCCCCCCCC C CCCCCCCCCC 2.85%HC1220140087in vivo