dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: Insulin-degrading enzyme

UniprotKB/SwissProt ID: IDE_MOUSE (Q9JHR7)

Gene Name: Ide

Organism: Mus musculus (Mouse).

Function: Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell membrane. Secreted.

Graphical Visualization of S-nitrosylation Sites:

Overview of Protein S-nitrosylation Sites with Functional and Structural Information

InterPro ID	Domain
IPR001431
IPR007863
IPR011237
IPR011249
IPR011765

The S-nitrosylation sites of IDE_MOUSE

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	Substrate Motifs	PubMed ID	Experiment
1	414	EGPQEWVFQE C KDLNAVAFRF	CCCCHHHHHH H HHHHHHHHHC	2.63%	MC03	20925432	in vivo
2	904	LDKPKKLSAE C AKYWGEIISQ	HHCCCCHHHH H HHHHHHHHHC	3.86%	MC06	20925432	in vivo

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