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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Isocitrate dehydrogenase [NADP], mitochondrial

UniprotKB/SwissProt ID: IDHP_MOUSE (P54071)

Gene Name: Idh2

Organism: Mus musculus (Mouse).

Function: Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion.

Network with metabolic pathway:
Kegg map ID Pathway Link
map00020Citrate cycle (TCA cycle)
map00480Glutathione metabolism
map04146Peroxisome
map012102-Oxocarboxylic acid metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001804
IPR004790
The S-nitrosylation sites of IDHP_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1113ATQKYSVAVK C ATITPDEARV CCCCCCHHCC C CCEEEECCEE 3.03%MC0122178444-
2113ATQKYSVAVK C ATITPDEARV CCCCCCHHCC C CCEEEECCEE 3.03%MC0121278135in vitro
3113ATQKYSVAVK C ATITPDEARV CCCCCCHHCC C CCEEEECCEE 3.03%MC0120837516in vivo
4113ATQKYSVAVK C ATITPDEARV CCCCCCHHCC C CCEEEECCEE 3.03%MC0122865876in vivo
5154GGTVFREPII C KNIPRLVPGW CCCCEEEEEE E ECCCCCCCCC 2.60%MC0421278135in vitro
6154GGTVFREPII C KNIPRLVPGW CCCCEEEEEE E ECCCCCCCCC 2.60%MC0422865876in vivo
7235DESISGFAHS C FQYSIQKKWP EECCCCCCCC C CCCCEEEEEC 1.44%MC0522865876in vivo
8308LKSSGGFVWA C KNYDGDVQSD HHHHHHHHHH H HHHHHCCCCE 1.40%MC0821278135in vitro
9308LKSSGGFVWA C KNYDGDVQSD HHHHHHHHHH H HHHHHCCCCE 1.40%MC0822865876in vivo
10336SLGLMTSVLV C PDGKTIEAEA HHHHHHHHHH H HHHHHHHHHC 1.91%MC0721278135in vitro
11336SLGLMTSVLV C PDGKTIEAEA HHHHHHHHHH H HHHHHHHHHC 1.91%MC0722865876in vivo
12402IRFAQTLEKV C VQTVESGAMT HHHHCCCHHH C CCCCCCCCCC 2.51%MC0821278135in vitro
13402IRFAQTLEKV C VQTVESGAMT HHHHCCCHHH C CCCCCCCCCC 2.51%MC0822865876in vivo
14418SGAMTKDLAG C IHGLSNVKLN CCCCCCEEEE C CCCCCCCCCC 1.40%MC0622178444-
15418SGAMTKDLAG C IHGLSNVKLN CCCCCCEEEE C CCCCCCCCCC 1.40%MC0621278135in vitro
16418SGAMTKDLAG C IHGLSNVKLN CCCCCCEEEE C CCCCCCCCCC 1.40%MC0620837516in vivo
17418SGAMTKDLAG C IHGLSNVKLN CCCCCCEEEE C CCCCCCCCCC 1.40%MC0622865876in vivo