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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Eukaryotic initiation factor 4A-I

UniprotKB/SwissProt ID: IF4A1_MOUSE (P60843)

Gene Name: Eif4a1

Synonyms: Ddx2a, Eif4a

Organism: Mus musculus (Mouse).

Function: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Network with metabolic pathway:
Kegg map ID Pathway Link
map03013RNA transport
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000629
IPR001650
IPR011545
IPR014001
IPR014014
IPR014021

The S-nitrosylation sites of IF4A1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
166SAIQQRAILP C IKGYDVIAQA CHHHHHHHHH H HCCCCEEEEE 4.50%MC0620925432in vivo
2131MALGDYMGAS C HACIGGTNVR HHHHCCCCCE E EEEECCCCHH 2.03%MC1320925432in vivo
3134GDYMGASCHA C IGGTNVRAEV HCCCCCEEEE E ECCCCHHHHH 1.01%MC0520925432in vivo