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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Eukaryotic translation initiation factor 5A-2

UniprotKB/SwissProt ID: IF5A2_HUMAN (Q9GZV4)

Gene Name: EIF5A2

Organism: Homo sapiens (Human).

Function: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity). Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus, nuclear pore complex (By similarity). Note=Hypusine modification promotes the nuclear export and c

Protein disease:
Disease database Database Entry Disease information
OMIM605782EUKARYOTIC TRANSLATION INITIATION FACTOR 5A2; EIF5A2
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001884
IPR008991
IPR012340
IPR014722

The S-nitrosylation sites of IF5A2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
173IFTGKKYEDI C PSTHNMDVPN CCCCEEEEEE E CCCCEEEECC 3.17%HC122212679in vitro
273IFTGKKYEDI C PSTHNMDVPN CCCCEEEEEE E CCCCEEEECC 3.17%HC1222126794in vivo