logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Eukaryotic translation initiation factor 6

UniprotKB/SwissProt ID: IF6_HUMAN (P56537)

Gene Name: EIF6

Synonyms: EIF3A, ITGB4BP

Organism: Homo sapiens (Human).

Function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.

Network with metabolic pathway:
Kegg map ID Pathway Link
map03008Ribosome biogenesis in eukaryotes
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR002769

The S-nitrosylation sites of IF6_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
111MAVRASFENN C EIGCFAKLTN CEEEEEEECC C CEEEEEEEEC 6.42%HC0122178444-
215ASFENNCEIG C FAKLTNTYCL EEEECCCCEE E EEEEECCEEE 3.54%HC0622178444-