UniprotKB/SwissProt ID: IL1RA_HUMAN (P18510)
Gene Name: IL1RN
Synonyms: IL1F3, IL1RA
Organism: Homo sapiens (Human).
Function: Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Isoform 1: Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm. Isoform 4: Cytoplasm.
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