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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Integrin-linked kinase-associated serine/threonine phosphatase 2C

UniprotKB/SwissProt ID: ILKAP_HUMAN (Q9H0C8)

Gene Name: ILKAP

Organism: Homo sapiens (Human).

Function: Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000222
IPR001932
IPR014045
IPR015655

The S-nitrosylation sites of ILKAP_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1190VISVEKTVKR C LLDTFKHTDE CCCHHHHHHH H HHHHHHHHHH 3.52%HC0919483679in vivo