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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Inositol monophosphatase 1

UniprotKB/SwissProt ID: IMPA1_HUMAN (P29218)

Gene Name: IMPA1

Synonyms: IMPA

Organism: Homo sapiens (Human).

Function: Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol- phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1- phosphate, beta-glycerophosphate, and 2'-AMP as substrates.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00562Inositol phosphate metabolism
map04070Phosphatidylinositol signaling system
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000146
IPR000760

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1AWB X-ray 2.50 A A/B2-277Link
1IMA X-ray 2.30 A A/B1-277Link
1IMB X-ray 2.20 A A/B1-277Link
1IMC X-ray 2.60 A A/B1-277Link
1IMD X-ray 2.60 A A/B1-277Link
1IME X-ray 2.25 A A/B1-277Link
1IMF X-ray 2.50 A A1-277Link
2HHM X-ray 2.10 A A/B2-277Link
4AS4 X-ray 1.70 A A/B1-277Link

The S-nitrosylation sites of IMPA1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1184MVLSNMEKLF C IPVHGIRSVG HHHHHHHHHH C CCCCEEEEHH 5.08%HC0419483679in vivo