Protein Name: Inosine triphosphate pyrophosphatase
|
UniprotKB/SwissProt ID: ITPA_HUMAN (Q9BY32)
Gene Name: ITPA
Synonyms: C20orf37
Organism: Homo sapiens (Human).
Function: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm.
| PDB : ( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. ) |
|
Protein disease:
|
Disease database |
Database Entry |
Disease information | HPRD | 08856 | Inosine triphosphatase deficiency |
|
Network with metabolic pathway:
|
|
Graphical Visualization of S-nitrosylation Sites:
|
Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
|