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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Junctophilin-1

UniprotKB/SwissProt ID: JPH1_MOUSE (Q9ET80)

Gene Name: Jph1

Synonyms: Jp1

Organism: Mus musculus (Mouse).

Function: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein. Note=Predominantly on the plasma membrane. The transmembrane domain i

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR003409

The S-nitrosylation sites of JPH1_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
129EEGKAHGHGI C TGPKGQGEYS HCCCEEEEEE E EECCCCCEEE 4.21%MC0121278135in vitro