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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Adenylate kinase isoenzyme 1

UniprotKB/SwissProt ID: KAD1_HUMAN (P00568)

Gene Name: AK1

Organism: Homo sapiens (Human).

Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Protein disease:
Disease database Database Entry Disease information
HPRD00046Adenylate kinase deficiency, hemolytic anemia due to
Network with metabolic pathway:
Kegg map ID Pathway Link
map00230Purine metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000850
IPR006267
IPR011769

The S-nitrosylation sites of KAD1_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
125GGPGSGKGTQ C EKIVQKYGYT CCCCCCHHHH H HHHHHHCCCC 6.05%HC0524105792-
2187GSVDSVFSQV C THLDALK--- CCHHHHHHHH H HHHHHCC 1.21%HC0524105792-