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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Adenylate kinase 2, mitochondrial

UniprotKB/SwissProt ID: KAD2_HUMAN (P54819)

Gene Name: AK2

Synonyms: ADK2

Organism: Homo sapiens (Human).

Function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion intermembrane space.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00230Purine metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000850
IPR006259
IPR007862
IPR011769

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2C9Y X-ray 2.10 A A1-239Link

The S-nitrosylation sites of KAD2_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
140TQAPRLAENF C VCHLATGDML HHHHHHHHHC C CCEEEHHHHH 4.87%HC0624105792-
242APRLAENFCV C HLATGDMLRA HHHHHHHCCC C EEEHHHHHHH 1.98%HC0724105792-
342APRLAENFCV C HLATGDMLRA HHHHHHHCCC C EEEHHHHHHH 1.98%HC0725040305in vivo
492LIEKNLETPL C KNGFLLDGFP HHHHHHHCCC C CCCEEEECCC 3.20%HC0124105792-
592LIEKNLETPL C KNGFLLDGFP HHHHHHHCCC C CCCEEEECCC 3.20%HC0119483679in vivo
6232SILAAFSKAT C KDLVMFI--- HHHHHHHHCC C CCEEEEC 3.74%HC0424105792-