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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Kynurenine--oxoglutarate transaminase 3

UniprotKB/SwissProt ID: KAT3_MOUSE (Q71RI9)

Gene Name: Ccbl2

Synonyms: Kat3

Organism: Mus musculus (Mouse).

Function: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00380Tryptophan metabolism
map00450Selenocompound metabolism
map05204Chemical carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001176
IPR004839
IPR015421
IPR015424

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
2ZJG X-ray 3.00 A A/B42-451Link
3E2F X-ray 2.59 A A/B42-451Link
3E2Y X-ray 2.26 A A/B42-451Link
3E2Z X-ray 2.81 A A/B42-451Link

The S-nitrosylation sites of KAT3_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1338IDIKRMDDPE C YFNSLPKELE HHHHHHHHHH H HHHHHHHHHH 5.98%MC0121278135in vitro
2417KLTAIPVSAF C DSKSKPHFEK CEEEECCCCC C CCCCCCCCCC 6.05%MC0421278135in vitro
3432KPHFEKLVRF C FIKKDSTLDA CCCCCCEEEE E EECCHHHHHH 2.12%MC0721278135in vitro