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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Calcium/calmodulin-dependent protein kinase type II subunit alpha

UniprotKB/SwissProt ID: KCC2A_MOUSE (P11798)

Gene Name: Camk2a

Organism: Mus musculus (Mouse).

Function: CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Isoform Alpha KAP: Cytoplasm (Probable). Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).

PDB :
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Network with metabolic pathway:
Kegg map ID Pathway Link
map04720Long-term potentiation
map04740Olfactory transduction
map04066HIF-1 signaling pathway
map04722Neurotrophin signaling pathway
map04725Cholinergic synapse
map04728Dopaminergic synapse
map04912GnRH signaling pathway
map04971Gastric acid secretion
map05031Amphetamine addiction
map05214Glioma
map04012ErbB signaling pathway
map04020Calcium signaling pathway
map04114Oocyte meiosis
map04310Wnt signaling pathway
map04916Melanogenesis
map05152Tuberculosis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000719
IPR002290
IPR008271
IPR011009
IPR013543
IPR015742

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
1HKX X-ray 2.65 A A/B/C/D/E/F/G/H/I/J/K/L/M/N336-478Link

The S-nitrosylation sites of KCC2A_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1280WISHRSTVAS C MHRQETVDCL CCCCCCCCCC C CCCCCCHHHH 1.60%MC0119101475-