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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Potassium voltage-gated channel subfamily A member 2

UniprotKB/SwissProt ID: KCNA2_MOUSE (P63141)

Gene Name: Kcna2

Organism: Mus musculus (Mouse).

Function: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Regulates neuronal excitability and is involved in non-rapid eye movement (NREM) sleep.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Membrane; Multi-pass membrane protein.

Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000210
IPR003091
IPR003131
IPR003968
IPR003972
IPR004049
IPR005821
IPR011333

The S-nitrosylation sites of KCNA2_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1482FREENLKTAN C TLANTNYVNI CCCCCCCCCC C CCCCCCCCCC 2.82%MC0824895380-