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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Creatine kinase B-type

UniprotKB/SwissProt ID: KCRB_HUMAN (P12277)

Gene Name: CKB

Synonyms: CKBB

Organism: Homo sapiens (Human).

Function: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm.

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:
Kegg map ID Pathway Link
map00330Arginine and proline metabolism
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000749
IPR014746

3D Structure Databases:
3D structure databases
EntryMethodResolution (A)ChainPositionsView
3B6R X-ray 2.00 A A/B1-381Link
3DRB X-ray 2.00 A A/B1-381Link
3DRE X-ray 2.20 A A/B1-381Link

The S-nitrosylation sites of KCRB_HUMAN

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1254GNMKEVFTRF C TGLTQIETLF CCHHHHHHHH H HHHHHHHHHH 2.38%HC0125040305in vivo
2254GNMKEVFTRF C TGLTQIETLF CCHHHHHHHH H HHHHHHHHHH 2.38%HC0119483679in vivo