Protein Name: KH domain-containing, RNA-binding, signal transduction-associated protein 1
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UniprotKB/SwissProt ID: KHDR1_MOUSE (Q60749)
Gene Name: Khdrbs1
Organism: Mus musculus (Mouse).
Function: Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)- containing RNA species.
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Membrane.
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Graphical Visualization of S-nitrosylation Sites:
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Overview of Protein S-nitrosylation Sites with Functional and Structural Information | |
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