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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Protein kinase C gamma type

UniprotKB/SwissProt ID: KPCG_MOUSE (P63318)

Gene Name: Prkcg

Synonyms: Pkcc, Pkcg, Prkcc

Organism: Mus musculus (Mouse).

Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contribute to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress. Phosphorylates p53/TP53 and promotes p53/TP53- dependent apoptosis in response to DNA damage (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region (By similarity). Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell projection, dendrite (By similarity). Note=Translocates to synaptic membranes on stimulation.

Network with metabolic pathway:
Kegg map ID Pathway Link
map04720Long-term potentiation
map04960Aldosterone-regulated sodium reabsorption
map04961Endocrine and other factor-regulated calcium reabsorption
map05143African trypanosomiasis
map05223Non-small cell lung cancer
map04066HIF-1 signaling pathway
map04370VEGF signaling pathway
map04540Gap junction
map04650Natural killer cell mediated cytotoxicity
map04666Fc gamma R-mediated phagocytosis
map04670Leukocyte transendothelial migration
map04723Retrograde endocannabinoid signaling
map04724Glutamatergic synapse
map04725Cholinergic synapse
map04726Serotonergic synapse
map04727GABAergic synapse
map04728Dopaminergic synapse
map04730Long-term depression
map04970Salivary secretion
map04971Gastric acid secretion
map04972Pancreatic secretion
map05031Amphetamine addiction
map05032Morphine addiction
map05146Amoebiasis
map05214Glioma
map04010MAPK signaling pathway
map04012ErbB signaling pathway
map04020Calcium signaling pathway
map04070Phosphatidylinositol signaling system
map04150mTOR signaling pathway
map04270Vascular smooth muscle contraction
map04310Wnt signaling pathway
map04510Focal adhesion
map04530Tight junction
map04916Melanogenesis
map05161Hepatitis B
map05200Pathways in cancer
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR000008
IPR000719
IPR000961
IPR002219
IPR002290
IPR008271
IPR008973
IPR011009
IPR014375
IPR015745

The S-nitrosylation sites of KPCG_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
1296YNVPVADADN C SLLQKFEACN CCCCCCCCCC H HHHHHHCCCC 2.89%MC0422178444-
2296YNVPVADADN C SLLQKFEACN CCCCCCCCCC H HHHHHHCCCC 2.89%MC0416418269in vitro
3305NCSLLQKFEA C NYPLELYERV CHHHHHHHCC C CCCCCCCCCC 3.84%MC0324895380-