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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Pyruvate kinase PKM

UniprotKB/SwissProt ID: KPYM_MOUSE (P52480)

Gene Name: Pkm

Synonyms: Pk3, Pkm2, Pykm

Organism: Mus musculus (Mouse).

Function: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation (By similarity).

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm (By similarity). Nucleus (By similarity).

Network with metabolic pathway:
Kegg map ID Pathway Link
map00010Glycolysis / Gluconeogenesis
map00230Purine metabolism
map00620Pyruvate metabolism
map04930Type II diabetes mellitus
map05203Viral carcinogenesis
Graphical Visualization of S-nitrosylation Sites:
Overview of Protein S-nitrosylation Sites with Functional and Structural Information
InterPro ID Domain
IPR001697
IPR011037
IPR015793
IPR015794
IPR015795
IPR015813

The S-nitrosylation sites of KPYM_MOUSE

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site Substrate Motifs PubMed ID Experiment
131AMADTFLEHM C RLDIDSAPIT CCHHHHHHHH H CCCCCCCCCC 4.16%MC0921278135in vitro
231AMADTFLEHM C RLDIDSAPIT CCHHHHHHHH H CCCCCCCCCC 4.16%MC0922865876in vivo
349PITARNTGII C TIGPASRSVE CCCCCCCEEE E EECCCCCCHH 1.83%MC0522588120-
449PITARNTGII C TIGPASRSVE CCCCCCCEEE E EECCCCCCHH 1.83%MC0524895380-
549PITARNTGII C TIGPASRSVE CCCCCCCEEE E EECCCCCCHH 1.83%MC0524926564-
649PITARNTGII C TIGPASRSVE CCCCCCCEEE E EECCCCCCHH 1.83%MC0520925432in vivo
749PITARNTGII C TIGPASRSVE CCCCCCCEEE E EECCCCCCHH 1.83%MC0521278135in vitro
849PITARNTGII C TIGPASRSVE CCCCCCCEEE E EECCCCCCHH 1.83%MC0522865876in vivo
9152ITLDNAYMEK C DENILWLDYK EEECHHHCCC C CCCEEEECCC 5.17%MC1322588120-
10152ITLDNAYMEK C DENILWLDYK EEECHHHCCC C CCCEEEECCC 5.17%MC1324895380-
11152ITLDNAYMEK C DENILWLDYK EEECHHHCCC C CCCEEEECCC 5.17%MC1324926564-
12152ITLDNAYMEK C DENILWLDYK EEECHHHCCC C CCCEEEECCC 5.17%MC1321278135in vitro
13152ITLDNAYMEK C DENILWLDYK EEECHHHCCC C CCCEEEECCC 5.17%MC1322865876in vivo
14165NILWLDYKNI C KVVEVGSKIY CEEEECCCCH H HHHCCCCEEE 3.70%MC1321278135in vitro
15165NILWLDYKNI C KVVEVGSKIY CEEEECCCCH H HHHCCCCEEE 3.70%MC1322865876in vivo
16326RCNRAGKPVI C ATQMLESMIK HHHHHCCCEE E EEHHHHHHHC 3.23%MC0121278135in vitro
17326RCNRAGKPVI C ATQMLESMIK HHHHHCCCEE E EEHHHHHHHC 3.23%MC0122865876in vivo
18358VANAVLDGAD C IMLSGETAKG HHHHHHCCCC E EEEECCCCCC 1.63%MC0321278135in vitro
19358VANAVLDGAD C IMLSGETAKG HHHHHHCCCC E EEEECCCCCC 1.63%MC0322865876in vivo
20423AVGAVEASFK C CSGAIIVLTK HHHHHHHHHH C CCCEEEEECC 1.79%MC1320925432in vivo
21424VGAVEASFKC C SGAIIVLTKS HHHHHHHHHC C CCEEEEECCC 4.30%MC0324926564-
22424VGAVEASFKC C SGAIIVLTKS HHHHHHHHHC C CCEEEEECCC 4.30%MC0320925432in vivo
23474HLYRGIFPVL C KDAVLNAWAE CEEECEEEEE E CCCCCCCHHH 3.69%MC1124895380-
24474HLYRGIFPVL C KDAVLNAWAE CEEECEEEEE E CCCCCCCHHH 3.69%MC1120925432in vivo
25474HLYRGIFPVL C KDAVLNAWAE CEEECEEEEE E CCCCCCCHHH 3.69%MC1121278135in vitro
26474HLYRGIFPVL C KDAVLNAWAE CEEECEEEEE E CCCCCCCHHH 3.69%MC1122865876in vivo