dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: Thymidylate kinase

UniprotKB/SwissProt ID: KTHY_HUMAN (P23919)

Gene Name: DTYMK

Synonyms: CDC8, TMPK, TYMK

Organism: Homo sapiens (Human).

Function: Catalyzes the conversion of dTMP to dTDP.

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

PDB :
( If your security settings prevent Jmol from running, please register http://140.138.144.145/ as a safe location in your Java settings. )

Network with metabolic pathway:

Kegg map ID	Pathway	Link
map00240	Pyrimidine metabolism

Graphical Visualization of S-nitrosylation Sites:

Overview of Protein S-nitrosylation Sites with Functional and Structural Information

3D Structure Databases:


3D structure databases
Entry	Method	Resolution (A)	Chain	Positions	View
1E2D	X-ray	1.65 A	A	1-212	Link
1E2E	X-ray	2.00 A	A	1-212	Link
1E2F	X-ray	1.60 A	A	1-212	Link
1E2G	X-ray	1.70 A	A	1-212	Link
1E2Q	X-ray	1.70 A	A	1-212	Link
1E98	X-ray	1.90 A	A	1-212	Link
1E99	X-ray	1.80 A	A	1-212	Link
1E9A	X-ray	1.60 A	A	1-212	Link
1E9B	X-ray	1.70 A	A	1-212	Link
1E9C	X-ray	1.60 A	A	1-212	Link
1E9D	X-ray	1.70 A	A	1-212	Link
1E9E	X-ray	1.60 A	A	1-212	Link
1E9F	X-ray	1.90 A	A	1-212	Link
1NMX	X-ray	1.70 A	A	1-212	Link
1NMY	X-ray	1.60 A	A	4-212	Link
1NMZ	X-ray	1.75 A	A	1-212	Link
1NN0	X-ray	1.60 A	A	1-212	Link
1NN1	X-ray	1.90 A	A	1-212	Link
1NN3	X-ray	1.55 A	A	1-212	Link
1NN5	X-ray	1.50 A	A	1-212	Link
2XX3	X-ray	2.00 A	A	1-212	Link

The S-nitrosylation sites of KTHY_HUMAN

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	Substrate Motifs	PubMed ID	Experiment
1	31	TQSRKLVEAL C AAGHRAELLR		2.92%	HC01	22178444	-
2	31	TQSRKLVEAL C AAGHRAELLR		2.92%	HC01	19483679	in vivo

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